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Observation on therapeutic efficacy of ursodeoxycholic acid in Chinese patients with primary biliary

Jiangyi Zhu, Yongquan Shi, Xinmin Zhou, Zengshan Li, Xiaofeng Huang, Zheyi Han, Jianhong Wang, Ruian Wang, Jie Ding, Kaichun Wu, Ying Han, Daiming Fan

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 255-263 doi: 10.1007/s11684-012-0227-1

Abstract:

The efficacy of ursodeoxycholic acid (UDCA) on long-term outcome of primary biliary cirrhosis (PBCWe aimed to assess the therapeutic effect of UDCA on Chinese patients with PBC.

Keywords： primary biliary cirrhosis     ursodeoxycholic acid     Chinese     biochemical response     therapeutic efficacy    

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Modified Therapeutic Antibodies: Improving Efficacy Review

Ji-Min Dai, Xue-Qin Zhang, Jing-Yao Dai, Xiang-Min Yang, Zhi-Nan Chen

Engineering 2021, Volume 7, Issue 11,   Pages 1529-1540 doi: 10.1016/j.eng.2020.06.030

Abstract:

The prosperity of the biotherapeutics market reflects the feasibility and effectiveness of therapeuticsuch as impeded binding, reduced effector functions, and frequent adverse reactions, modifications of therapeutichalf-life in circulation, effectiveness toward target cells and, ultimately, to achieve overall improved efficacyThis review recapitulates the international progress that has been achieved with modified therapeutic

Keywords： Therapeutic antibody     Modification     Efficacy     Antigen     Antibody–drug conjugate     Bispecific antibody    

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A review of the safety and efficacy of current COVID-19 vaccines

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 39-55 doi: 10.1007/s11684-021-0893-y

Abstract: This study reviewed the efficacy/effectiveness, immunogenicity, and safety profile of the 12 most progressedOverall, most of the current vaccines have shown safety and efficacy/effectiveness during actual clinical

Keywords： COVID-19     SARS-CoV-2     vaccine     safety     efficacy     effectiveness     immunogenicity    

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Circulating microRNAs in cardiovascular diseases: from biomarkers to therapeutic targets

Feng Wang,Chen Chen,Daowen Wang

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 404-418 doi: 10.1007/s11684-014-0379-2

Abstract: functions of circulating miRNAs in cardiovascular system but also inform the development of miRNAs therapeuticthe potential roles of circulating miRNAs in a variety of cardiovascular diseases from biomarkers to therapeutic

Keywords： microRNA     cardiovascular disease     biomarkers     therapeutic target    

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Brown and beige fat: the metabolic function, induction, and therapeutic potential

Shuwen Qian,Haiyan Huang,Qiqun Tang

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 162-172 doi: 10.1007/s11684-015-0382-2

Abstract: induce the development, the activation of brown or beige adipose tissue, which seem to be promising for therapeutic

Keywords： brown adipocyte     beige adipocyte     metabolism     obesity    

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Screening Reveals Potential Targets of Bioactive Compounds from a Herbal Prescription Based on the TherapeuticEfficacy of Yinchenhao Tang for Jaundice Syndrome Article

Hui Xiong, Ai-Hua Zhang, Ya-Jing Guo, Xiao-Hang Zhou, Hui Sun, Le Yang, Heng Fang, Guang-Li Yan, Xi-Jun Wang

Engineering 2021, Volume 7, Issue 9,   Pages 1293-1305 doi: 10.1016/j.eng.2020.12.016

Abstract: Although many studies have examined the efficacy and active ingredients of YCHT, there is still a lackwere further verified by enzyme-linked immunosorbent assay (ELISA), which indicated that YCHT exerts therapeuticintegrated strategy can be successfully applied for the effective discovery of the active compounds and therapeutic

Keywords： Efficacy     Bioactive compound     Small molecule     Targets     Herbal medicine     Metabolomics    

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Molecular mechanisms and therapeutic strategies of vulnerable atherosclerotic plaques

Wen-Qiang CHEN MD, Yun ZHANG MD, PhD, FACC,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 36-42 doi: 10.1007/s11684-010-0020-y

Abstract: Vulnerable atherosclerotic plaque rupture leading to thrombosis is the major cause of acute coronary syndrome (ACS). Studies on the pathophysiologic mechanism of both ACS and plaque stabilizing treatment are driving the development of animal models of vulnerable plaque. In our laboratory, we established animal models of plaque rupture and thrombosis in rabbits and mice that are similar to human plaque rupture. Potential mechanisms involved in plaque vulnerability were studied from the inflammation-immunity, proliferation-apoptosis, oxidative stress and biomechanics aspects. Imaging markers and biomarkers were used to detect vulnerable plaques, including high frequency duplex ultrasound, intravascular ultrasound (IVUS), intravascular ultrasound elastography, magnetic resonance imaging (MRI) and inflammatory markers. Effective gene and drug strategies to treat vulnerable plaques were explored.

Keywords： vulnerable plaque     animal models     mechani-sm     detection     treatment    

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Heterogeneous influence of individuals’ behavior on mask efficacy in gathering environments

Frontiers of Engineering Management   Pages 550-562 doi: 10.1007/s42524-022-0193-5

Abstract: Although masks can slow down the spread of viruses, their efficacy in gathering environments involvingThe heterogeneity of individuals can cause mask efficacy in a specific gathering environment to be differentfrom the baseline efficacy in general society.This study contributes to the accurate evaluation of mask efficacy in various gathering environments

Keywords： COVID-19     masks     behavioral heterogeneity     asymptomatic infection    

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Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies

Guangbiao Zhou, Saijuan Chen, Zhu Chen

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 117-125 doi: 10.1007/s11684-020-0773-x

Abstract: the insights in the virus, the responses of the host cells, the cytokine release syndrome, and the therapeutic

Keywords： COVID-19     SARS-CoV-2     pathogenesis     evidence-based medicine     control and therapeutic strategies    

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Retrospective study of the efficacy and complication of thoracoabdominal incision for nephrectomy: a

Minggen YANG, Xiaokun ZHAO

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 191-196 doi: 10.1007/s11684-009-0026-5

Abstract: Efficacy and complication was comparable for thoracoabdominal and flank incisions in terms of incisional

Keywords： surgery     renal tumors     nephrectomy    

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Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies

Peter B. Alexander,Xiao-Fan Wang

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 134-138 doi: 10.1007/s11684-015-0396-9

Abstract:

Drug resistance is a major factor that limits the efficacy of targeted cancer therapies.of resistance to receptor tyrosine kinase inhibitors, which are the most prevalent class of targeted therapeutic

Keywords： targeted therapy     drug resistance     receptor tyrosine kinases     cancer    

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Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review

Amma Owusu-Ansah,Sung Hee Choi,Agne Petrosiute,John J. Letterio,Alex Yee-Chen Huang

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 46-56 doi: 10.1007/s11684-015-0375-1

Abstract: important intermediate in these pathophysiological processes and is therefore an important target for therapeuticexpression of anti-oxidant enzymes and is emerging as a protein whose function can be exploited with therapeuticThe article concludes with a perspective on the potential of the various therapeutic interventions to

Keywords： oxidative stress     Nrf2     triterpenoids     sickle cell disease     vaso-occlusion     CDDO-Me    

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Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic

Frontiers of Medicine doi: 10.1007/s11684-023-1050-6

Abstract: pancreatic cancer, encompassing its epidemiology, genomic characterization, risk factors, diagnosis, therapeuticpancreatic cancer research and discuss the latest combinations of pancreatic cancer biomarkers and their efficacythe primary mechanisms underlying treatment resistance in this malignancy, illustrating the latest therapeutic

Keywords： pancreatic cancer     cancer screening     single cell     molecular alterations     precancerous lesion     therapy resistance    

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Base editors: development and applications in biomedicine

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 359-387 doi: 10.1007/s11684-023-1013-y

Abstract: summarize their applications in the biomedical field, and discuss future perspectives and challenges for therapeutic

Keywords： base editing     CBE     ABE     ADAR     DdCBE     disease model     therapeutic application    

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AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Megan A. Hatlen, Lan Wang, Stephen D. Nimer

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 248-262 doi: 10.1007/s11684-012-0206-6

Abstract: We also discuss potential therapeutic strategies for t(8;21) positive AML that involve targeting the

Keywords： AML1-ETO     mouse model     leukemia     t(8     21)     pathway hits     mutation     hematopoiesis     Kasumi-1     CD34+    

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Title Author Date Type Operation

Observation on therapeutic efficacy of ursodeoxycholic acid in Chinese patients with primary biliary

Jiangyi Zhu, Yongquan Shi, Xinmin Zhou, Zengshan Li, Xiaofeng Huang, Zheyi Han, Jianhong Wang, Ruian Wang, Jie Ding, Kaichun Wu, Ying Han, Daiming Fan

Journal Article

Modified Therapeutic Antibodies: Improving Efficacy

Ji-Min Dai, Xue-Qin Zhang, Jing-Yao Dai, Xiang-Min Yang, Zhi-Nan Chen

Journal Article

A review of the safety and efficacy of current COVID-19 vaccines

Journal Article

Circulating microRNAs in cardiovascular diseases: from biomarkers to therapeutic targets

Feng Wang,Chen Chen,Daowen Wang

Journal Article

Brown and beige fat: the metabolic function, induction, and therapeutic potential

Shuwen Qian,Haiyan Huang,Qiqun Tang

Journal Article

Screening Reveals Potential Targets of Bioactive Compounds from a Herbal Prescription Based on the TherapeuticEfficacy of Yinchenhao Tang for Jaundice Syndrome

Hui Xiong, Ai-Hua Zhang, Ya-Jing Guo, Xiao-Hang Zhou, Hui Sun, Le Yang, Heng Fang, Guang-Li Yan, Xi-Jun Wang

Journal Article

Molecular mechanisms and therapeutic strategies of vulnerable atherosclerotic plaques

Wen-Qiang CHEN MD, Yun ZHANG MD, PhD, FACC,

Journal Article

Heterogeneous influence of individuals’ behavior on mask efficacy in gathering environments

Journal Article

Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies

Guangbiao Zhou, Saijuan Chen, Zhu Chen

Journal Article

Retrospective study of the efficacy and complication of thoracoabdominal incision for nephrectomy: a

Minggen YANG, Xiaokun ZHAO

Journal Article

Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies

Peter B. Alexander,Xiao-Fan Wang

Journal Article

Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review

Amma Owusu-Ansah,Sung Hee Choi,Agne Petrosiute,John J. Letterio,Alex Yee-Chen Huang

Journal Article

Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic

Journal Article

Base editors: development and applications in biomedicine

Journal Article

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Megan A. Hatlen, Lan Wang, Stephen D. Nimer

Journal Article